iCMoB Funded Innovative Research Projects 2014-2021
| JFY 2020/2021 | ||
| Research Title | PI | Student/Researcher |
| Development of SARS-CoV-2 spike RBD Biosensor for the Screening of Patients with Coronavirus Disease of 2019 | Dr. Mutinda Kyama | |
| Development of Monoclonal Antibodies and Evaluation of Their Efficacy in The Neutralization of Naja Ashei (Large Brown Spitting Cobra) Venom and Detection of Envenomation | Dr. Mutinda Kyama | Ernest Ziem Manson |
| Molecular Biomarkers for Diagnosis of induced Endometriosis in Baboon Model | Dr. Mutinda Kyama | Irene Mwongeli Waita |
| Prevalence, Antifungal Susceptibility and Genotypic Characterization of Isolated Candida Species from Bloodstream Of CCU Patients In Nairobi Hospital, Kenya | Dr. Caroline Ngugi | Danait Andemichael Solomon |
| Antimicrobial Susceptibility Profiles And Molecular Basis Of Resistance Of Escherichia Coli And Klebsiella Pneumoniae Strains Isolated From Wastewaters In Nairobi And Its Environs, Kenya | Dr. Caroline Ngugi | Osborn Khasabuli |
| Lymphocyte Adaptor Protein Gene As A Molecular Marker For The Detection Of Essential Hypertension | Dr. Amos Mbugua | Caroline Wayua Mumo |
| Development of Bromelainencapsulated with Zinc Oxide Nanoparticles for Treatment of Gastrointestinal Parasites in Dairy Goats from Small Holder Farms in Greater Thika Region | Dr. Kenneth Ogila | Oduor Michael |
| Evaluation of Anti-Dengue Properties of Carica Papaya Leaf Extract Coated Silver Nanoparticles and in Silico Optimization of The Bioactive Compounds | Dr. Florence Ng’on’ga | Antonia Windkouni |
| In vitro Investigation of Acyclovir Derivatives Potency against Herpes simplex virus | Dr. Florence Ng’on’ga | Clive Nyaribo |
| Dissecting the Association of Major Transporters with Resistance to Antimalarial Drugs; Piperaquine, Lumefantrine and Amodiaquine in Plasmodium Berghei | Dr. Daniel Kiboi | Brendah Mureithi |
| Genetic Polymorphisms in Estrogen Metabolism Enzymes in Patients Diagnosed with Estrogen Receptor Positive Breast Cancer at Aga Khan University Hospital, Nairobi | Dr. Steven Ger | Mary Mureithi |
| Building a national capacity for research development and production of bacteriophage-based antibacterial agents against antimicrobial-resistant bacteria in Kenyan fish farms. | Dr. Josephine Kimani | |
| JFY 2018/2019 | ||
| Research Title | PI/Researchers | |
| Development of an Oral Dosage Form from Kenya Ruellia Prostrata Species for Management of Rheumatoid Arthritis | Dr. Christine Ong’ayo Wangia | |
| Drug Development of Nano formulated Azadirachta Indica as Anticancer Therapy | Judith Nwagbogu (PAUSTI) | |
| A Pre-Clinical Mouse Model to Test New Therapeutic Agents and New Diagnostic Biomarkers for Ovarian Cancer | Dr. Mutinda Kyama & Dr. Andrew Nyerere | |
| Development of Ph Responsive Smart Delivery Hydrogels for Wound Dressing Application | Edwin Shigwenya Madivoli | |
| Development of Methods of Detection and Characterization of MLN-Casual Viruses using Small RNA Transcriptome Profiling | Tanui Ronald (PAUSTI) | |
| HIV-1 Genetic Diversity, Tropism, Transmitted and Acquired drug Resistance Mutations Among HIV infected patients attending Comprehensive Care Clinic in Kisii Teaching and Referral Hospital, Kenya | Sepha Nyatichi Mabeya | |
| Evaluating the Medicinal Potential of the Crude Extracts and Peptides Isolated Peptides from Tympanotous Fuscatus Var Radula and Pachymelania | EGHIANRUWA, Queensley Adesuwa (PAUSTI) | |
| JFY 2017/2018 | ||
| Research Title | PI/Researchers | |
| Immunomodulatory and Plesctanthus Barbatus Extracts in Alloxan | Evelyn Kagendo Kirugara | |
| Genetic characterization and in vitro regeneration of Garcinia kola (Heckel)-A medicinal tree in Benin(West Africa) | Dadjo Colombe Pritania Adeline Fifamin (PAUSTI) | |
| HIV-1 Genetic Diversity, Viral Tropism, Transmitted and Acquired Drug Resistance Mutations among Patients attending Comprehensive Care Clinic in Kisii Teaching and Referral Hospital Kenya | Sepha Nyatichi Mabeya | |
| Antibacterial Properties of Medicinal Plants used among the Maasai Community in Kenya | Kariuki Mercy Wanjiru | |
| Comparative Analysis of Random Blood Glucose Levels in Serum Plasma and Whole Blood Using Glucose Oxidase and Hexokinase Methods | Joyce Muthoni Gachoki | |
| Genetic Characterization of Gametocyte Development Protein I and PFAPS-G in Plasmodium Falciparum Isolates Background | Josphat Kipsang Bungei | |
| Bio-prospecting for Antimicrobial and Anticancer Peptides from Marine Organisms Tympanotonus fuscatus var radula and Pachymelania aurita | EGHIANRUWA, Queensley Adesuwa (PAUSTI) | |
| Identification of Candidate Targets for retroviral Protease Inhibitors in Plasmodium Berghei | Noah Machuku Ochieku | |
| Molecular characterization of influenza A virus subtypes in baboon and identification of conserved regions as vaccine targets | Emmanuel Kulwa Bunuma | |
| Evaluation of Plasmodium Helical Interspersed Sub Telemeric (PHISTc) Proteins as Potential Anti-Malarial Vaccine Targets | Eunice Wavinya Kiamba | |
| Analysis of Genetic Diversity and Heat Shock Protein 70 (HSPS70) Gene Functional Polymorphisms for Heat Tolerance in Domesticated Rabbits in Kenya | Sharon Auma Owuor | |
| Development of point of care Molecular Diagnostics of Malaria in Kenya | Kenny Kimani Kamau | |
| Evaluation of Human Epidermal growth factor receptor-2/Neu and Hormonal receptor expression patterns in Breast Cancer from Fine Needle aspiration cytology | Dr. Mutinda C. Kyama | |
| Evaluation of Efficacy and Toxicity of Senna Didymoboytra Plant Extracts as Antimalarial Remedy | Grace Wambui Kimani | |
| Prevalence, Antimicrobial Susceptibility Profiles and Genetic Diversity of Isolates Obtained from Urine Samples of Pregnant Women Attending Antenatal Clinic at Pumwani Maternity Hospital, Kenya | Hellen A. Onyango | |
| Anticancer Potential of Selected Medicinal Plants (Tropical Area) | Mohamed Abd Elfattah Mohamed Hassen (PAUSTI) | |
| Improving Early Diagnosis of Cervical Squamous Intraepithelial Lesions Using P16INK4a Marker on Cell Blocks from Cervical Smears | Martha Wakio Maina | |
| Validation of a Smartphone based DNA real time PCR assay for the detection of Human Malaria at Point of Care | Lukoye John | |
| Evaluation of Anti-Plasmodium Soybean Extract | Nyandwaro Kevin Teya | |
| Evaluation of the Suitability of Human Solid Waste from Green Toilets System as Fertilizers for Agricultureal use | Ouma Shellemiah Otieno | |
| Carriage of Staphylococcus Aureus and the prevalence of Methicillin Resistant Staphylococcus Aureus among football players at Camp To yoyo Stadium | Bagio Emodoi Antony | |
| validation of selected ethno medicines used in Kenya with potential anti-malaria, analgesic and anti-typhoid agents | Prof. John Ochora | |
| Improvement of Disease Management; ‘Genotypic characterization of Mycobacterium tuberculosis Recovered from Newly Diagnosed, Repeat and TB-HIV co-infected Patients Reporting to Clinics in Western Kenya’ | Martin Owalla ogwang | |
| JFY 2016/2017 | ||
| Research Title | PI/Researchers | |
| The potental of transgenic (expressing mouse interferon gamma) Plasmodium berghei to induce malaria protection in mice | Ebenezer Ninyah Taylor (PAUSTI) | |
| Active prevalence of hepatitis C infection and molecularcharacterization if hepatitis C virus among patients in Rwanda | Esperance Umumararungu (PAUSTI) | |
| Validation of sarcosine as a potential antimalarial drug candidate when used singly with combination with quinolone and artemisinin based drugs | Jean Baptiste | |
| Genetic diversity of potato (Solanum tuberose) clones conserved in Ethiopia using Simple sequence repeat (SSR) markers | Hulubanche Tadele Kassa (PAUSTI) | |
| Repositioning of approved drugs for use against blood stage Plasmodium falciparum in Silico, in vitro and in vivo approach | Reagan Moseti Mogire | |
| Molecular markers associated with amodiaquine resistance in rodent malaria parasite Plasmodium berghei ANKA | Loise Ndungu | |
| Evaluating efficacy of small interfering RNAs in breaking seed domancy and developing protocols for regeneration and transformation of Rosa rubiginosa | Miloane Mokhobo | |
| Characterization of antibiotics and biosynthesized antibacterial silver nanoparticles from actinomycetes isoloated from industrial waste disposal sites | Kassahun Abebe Bizuye (PAUSTI) | |
| Evaluation of loop medicated isothermal amplication assay in the detection of falciparum malaria at the lake region in Kenya | James Gachugia Mwangi | |
| Prevalence of abnormal urine components in subjectively healthy food handlers attending regular medical checkup at KEMRI CMR | Mutua Boniface Wambua | |
| Characterization of human herpes virus type 8 among female sex works in Malinda kenya | Mirriam Mbithe Nzivo | |
| Physical activity dietary and nutritional status of hypertensive patients attending kiambu district hospital, Kiambu county Kenya | Jane Gatwiri Mbijiwe | |
| Genotype identification of toxoplasma gondii strains associated with toxoplasmosis in Kenya | Ngugi Jedidah Njeri | |
| Isolation and characterization of novel alkalithermophilic bacteria from the hot springs of lake Magadi | Eunice Mbuli Mulango | |
| Isolation and characterization of gut microbes present in wild and captive baboon population | Senelwa Davis Lugano | |
| Analysis of resistance of transgenic potato varieties to selected phytophthora infestans isolates | Ethel Webi | |
| Characterization of human T cell lymphotropic virus among intravenous drug users in Malindi, Kenya | Caroline Chepkorir Koech | |
| Polymorphism in growth hormone and myostatin gene associated with meat production traits in domesticated rabbits in Kenya | Festus Mutai Kiprono | |
| The utility of a low cost manual liquid based cytology in screening for precancerous lesions and cervical cancer | Onesmus Muia | |
| Differential antibiotic resistance of Helicobacter pylori in dyspeptic patients: a study on genetic and phenotypic diversity among clinical isolation from gastric corpus and antrum | Catherine Njeri Mwangi | |
| Genotypic characterization of mycobacterium tuberculosis recovered for newly diagnosed, repeat and TB HIV confected patients reporting to clinics in Western Kenya | Martin Owallah | |
| Antimicrobial , immunomodulatory effects, safety evaluation and partial characterization of Kenyan Cape Gooseberry (Physalis Peruviana) extracts | Peter Karanja Kamau | |
| JFY 2015/2016 | ||
| Research Title | PI/Researchers | |
| Phytochemical and pharmacological evaluation of medicinal plants used as contraceptives in Siaya county, Kenya | Rechab Sylvester Odhiambo | |
| Dietary regulation of highly polyunsaturated fatty acids content in farmed tilapia (Oreochromis niloticus) and cat fish (Clarias gariepinus) | Kevin Mbogo Omolo | |
| Prevalece, plasmids and antibiotic resistance correlation of enteric bacteria in waste water, surface water and drinking water biofilms in Nairobi river Basin, Kenya. | Mwangi Samuel Wambura | |
| Antimicrobial and cytotoxic effects of secondary metabolites from endophytic and epiphytic bacteria and fungi from marine algae of the Kenya coast. | Purity Kinya Kaaria | |
| Evaluating antiplasmodial activity of a novel compound in mouse model and in vitro | Muturi Njokah | |
| Determining the presence of fungal pathogens and concentration levels of aflatoxin in commonly used food spices in Kiambo county and the public health risks associated with consumption of the spices | Moses Odanga | |
| Pathophysiological manifestations in Olive baboons (Papio Anubis) experimentally infected with toxoplasma gondii strain isolated from free range chicken | Dr. David Muchina Kamau | |
| Antimicrobial, immunomodulatory effects, safety evaluation and partial characterization of Kenyan Cape Gooseberry (Physalis peruviana L) extracts. | Peter Karanja Kamau | |
| Functional determination of tricon protease in trypanosome brucei through site directed mutagenesis | Florence Atieno Ng’ong’a | |
| Molecular characterization of different aspergillus flavus isolates from different agroecological regions in Kenya. | Biwott Edwin Kimurgor | |
| Hypoglycemic potential and phytochemical screening of aloe secundiflora and aloe lateritia extracts in Alloxan induced diabetic mice. | Charles Makau Mbithi | |
| Seroprofile, genetic diversity, antiretroviral resistance and role of cytokines in defining disease progression among hepatitis B and HIV co-infected individuals visiting Mama Lucy hospital, Nairobi. | Sepha Nyatich Mabeya (PAUSTI) | |
| Antimicrobial, immunjomodulatory effects, safety evaluation and partial characterization of Kenyan Cape Gooseberry (Physalis peruviana L) extracts. | Peter Mochama Onkware | |
| JFY 2014/2015 | ||
| Research Title | PI/Researchers | |
| Impact of enclosures and afforestation on forage production in rangelands in West Pokot, Kenya | Regina Waiganjo | |
| Bio prospecting for Novel Antibiotics from soil actinomycets | Mercy Chepkurui | |
| Hybrid drugs: Future to malarial chemotherapy efficacy and toxicity of chloroquine derived hybrid drug in vitro and in vivo | Milka Wambui | |
| Bacterial diversity in the midnight of Anopheles gambiae mosquito vectors in selected parts of Kenya | Erastus Mwaringa | |
| Phylogeographer and population genetic structure of naked mole rate Heterocephalus glaber | Phillip Moshe | |
| Genetic background and functional polymorphisms of candidate gene for draught tolerance of indigenous chickens in Kenya | Kennedy Grace Moraa | |