iCMoB Funded Innovative Research Projects 2014-2023

JFY 2023/2024
Research Title PI Student/Researcher
Phytochemical Profiling and Molecular Mechanism of Hydnora Abyssinica and Vitex Doniana Against Cervical Cancer Cell Lines Prof. Mutinda Kyama

Amel Elbasyoun

Characterization and Antibacterial Activity of Environmental Lytic Bacteriophages Against Clinical Isolates of Multidrug-resistant Enterococcus Faecalis and Enterococcus Faecium  Dr. Andrew K. Nyerere

Oumarou Soro

Molecular Xenomonitoring of Onchocerca Volvulus in Kenya: Improved Control Towards Disease Elimination Dr. Amos Mbugua

Esther A. Omondi

Detection and Molecular Characterization of Human Cytomegalovirus Infection Among Pregnant Women Attending the Antenatal Clinic at Kenyatta National Hospital.

Prof. Rebecca Waihenya

Ruth W. Gicho

Assessment of the Role of Variant Surface Antigen Protein (Var2csa) In Antibody-Mediated Complement Activation in Pregnancy Associated Malaria

Dr. Kevin Mbogo

Alex R. Kiplagat

Correlation of Antimicrobial Resistance Profiles of Isolates Recovered from Patients’ Clinical Specimens and Those Recovered from Hospital Abiotic Surfaces of Kenyatta National Hospital

Dr. Mourine Kangogo

Joel S.K. Mukaya

Development of an Antimicrobial Surface Coatings Containing Metal/Metal Oxide Nanoparticles Synthesized using Non-Pathogenic Fungi Dr. Edwin Madivoli

Vincent M. Ngunjiri

JFY 2022/2023
Research Title PI Student/Researcher
Evaluation of endometrial cytology in detection of endometrial cancer and atypical hyperplasia Prof. Mutinda Kyama Eudia Kemei
Phytochemical profiling of selected male fertility enhancing medicinal plants from Meru county, Kenya Prof. Patrick Kareru Brenda Akinyi Ogwenya 
Prevalence, associated risk factors, antimicrobial profiles and genotypic characterization of campylobacter species in diarrheic children under five years at Mbagathi Hospital Nairobi Dr. Celestine Makobe Mr. Peter Abuom
Genotyping of virulence and antimicrobial resistant genes in biofilm forming Escherichia coli isolates from patients with Urinary tract infection in Kenya. Dr. Caroline Ngugi Shirleen Chelagat
Potential use of bacteriophage for pathogen reduction in sewage effluent and sludge. Case study: Ruai sewage treatment plant Dr. Juliah Khayeli Ms. Noreen Juma
Efficacy of nano-phytoconstituents from indigenous Kenyan medicinal plants against drug-resistant Mycobacteria tuberculosis (M. tb) Prof. Patrick Gachoki Kareru Brian Victor Otenda
Evaluation of a nitrogen removal system to limit water exchange for closed recirculating freshwater system using Down flow hanging sponge (DHS)– up flow sludge blanket system (USB) reactor in growing of Labeo spp. in Kenya  Dr. Robert Nesta Calvin Owuor Obondo
The dynamics of SARS CoV 2 specific T cell responses among the Kenyan population to guide diagnosis and treatment of SARS CoV 2 and other viral infection pandemics Dr. Amos Mbugua Gladwell Gathigia Ndoria
In vivo efficacy of anti-leishmanial activity of Allium sativum and Aloe secundiflora extracts. Dr. Christine Mutoro
Defining the Role of Plasmodium falciparum Proteasome Shuttle Proteins in Artemisinin Resistance Dr. Edinah Song’oro
JFY 2021/2022
Research Title PI Student/Researcher
Improving the socio-economic status of dairy goat farmers in Kiambu and Nyeri Counties by the control of Mastitis Dr. Caroline Ngugi
CRISPR_Cas9 based validation of SufS and ISCS genes association with drug resistance in Plasmodium falciparum Dr. Daniel Kiboi Beatrice M. Gachie
The immune response and physiological effects of covid-19 vaccine among health workers at Kenyatta university teaching, referral and research hospital Dr. Caroline Ngugi Joyce Muthoni Gachoki
Evaluation of The Effects of Dermaseptin B2 on Tumorigenesis in Vitro and in A Mouse Model with Rhabdomyosarcoma Prof. Fred Wamunyokoli Ahmed A. Abdille
Evaluation of β-Tubulin SNPs associated with drug resistance in soil-transmitted helminths Dr. Amos Mbugua Peterson M. Maingi
Development and evaluation of the performance efficiency for a low-cost solar-powered aquaponics system for small-holder farmers in Kenya Dr. Robert Nesta 
JFY 2020/2021
Research Title PI Student/Researcher
Development of SARS-CoV-2 spike RBD Biosensor for the Screening of Patients with Coronavirus Disease of 2019  Dr. Mutinda Kyama  
Development of Monoclonal Antibodies and Evaluation of Their Efficacy in The Neutralization of Naja Ashei (Large Brown Spitting Cobra) Venom and Detection of Envenomation Dr. Mutinda Kyama Ernest Ziem Manson
Molecular Biomarkers for Diagnosis of induced Endometriosis in Baboon Model  Dr. Mutinda Kyama Irene Mwongeli Waita
Prevalence, Antifungal Susceptibility and Genotypic Characterization of Isolated Candida Species from Bloodstream Of CCU Patients In Nairobi Hospital, Kenya  Dr. Caroline Ngugi Danait Andemichael Solomon
Antimicrobial Susceptibility Profiles And Molecular Basis Of Resistance Of Escherichia Coli And Klebsiella Pneumoniae Strains Isolated From Wastewaters In Nairobi And Its Environs, Kenya  Dr. Caroline Ngugi Osborn Khasabuli
Lymphocyte Adaptor Protein Gene As A Molecular Marker For The Detection Of Essential Hypertension  Dr. Amos Mbugua Caroline Wayua Mumo
Development of Bromelainencapsulated with Zinc Oxide Nanoparticles for Treatment of Gastrointestinal Parasites in Dairy Goats from Small Holder Farms in Greater Thika Region  Dr. Kenneth Ogila Oduor Michael
Evaluation of Anti-Dengue Properties of Carica Papaya Leaf Extract Coated Silver Nanoparticles and in Silico Optimization of The Bioactive Compounds Dr. Florence Ng’on’ga Antonia Windkouni
In vitro Investigation of Acyclovir Derivatives Potency against Herpes simplex virus  Dr. Florence Ng’on’ga Clive Nyaribo 
Dissecting the Association of Major Transporters with Resistance to Antimalarial Drugs; Piperaquine, Lumefantrine and Amodiaquine in Plasmodium Berghei Dr. Daniel Kiboi Brendah Mureithi
Genetic Polymorphisms in Estrogen Metabolism Enzymes in Patients Diagnosed with Estrogen Receptor Positive Breast Cancer at Aga Khan University Hospital, Nairobi Dr. Steven Ger Mary Mureithi
Building a national capacity for research development and production of bacteriophage-based antibacterial agents against antimicrobial-resistant bacteria in Kenyan fish farms.  Dr. Josephine Kimani  
JFY 2018/2019
Research Title PI/Researchers
Development of an Oral Dosage Form from Kenya Ruellia Prostrata Species for Management of Rheumatoid Arthritis Dr. Christine Ong’ayo Wangia
Drug Development of Nano formulated Azadirachta Indica as Anticancer Therapy Judith Nwagbogu (PAUSTI)
A Pre-Clinical Mouse Model to Test New Therapeutic Agents and New Diagnostic Biomarkers for Ovarian Cancer Dr. Mutinda Kyama & Dr. Andrew Nyerere
Development of Ph Responsive Smart Delivery Hydrogels for Wound Dressing Application Edwin Shigwenya Madivoli
Development of Methods of Detection and Characterization of MLN-Casual Viruses using Small RNA Transcriptome Profiling Tanui Ronald (PAUSTI)
HIV-1 Genetic Diversity, Tropism, Transmitted and Acquired drug Resistance Mutations Among HIV infected patients attending Comprehensive Care Clinic in Kisii Teaching and Referral Hospital, Kenya Sepha Nyatichi Mabeya
Evaluating the Medicinal Potential of the Crude Extracts and Peptides Isolated Peptides from Tympanotous Fuscatus Var Radula and Pachymelania EGHIANRUWA, Queensley Adesuwa (PAUSTI)
JFY 2017/2018
Research Title PI/Researchers
Immunomodulatory and Plesctanthus Barbatus Extracts in Alloxan Evelyn Kagendo Kirugara
Genetic characterization and in vitro regeneration of Garcinia kola (Heckel)-A medicinal tree in Benin(West Africa) Dadjo Colombe Pritania  Adeline Fifamin (PAUSTI)
HIV-1 Genetic Diversity, Viral Tropism, Transmitted and Acquired Drug Resistance Mutations among Patients attending Comprehensive Care Clinic in Kisii Teaching and Referral Hospital Kenya Sepha Nyatichi Mabeya
Antibacterial Properties of Medicinal Plants used among the Maasai Community in Kenya Kariuki Mercy Wanjiru
Comparative Analysis of Random Blood Glucose Levels in Serum Plasma and Whole Blood Using Glucose Oxidase and Hexokinase Methods Joyce Muthoni Gachoki
Genetic Characterization of Gametocyte Development Protein I and PFAPS-G in Plasmodium Falciparum Isolates Background Josphat Kipsang Bungei
Bio-prospecting for Antimicrobial and Anticancer Peptides from Marine Organisms Tympanotonus fuscatus var radula and Pachymelania aurita EGHIANRUWA, Queensley Adesuwa (PAUSTI)
Identification of Candidate Targets for retroviral Protease Inhibitors in Plasmodium Berghei Noah Machuku Ochieku
Molecular characterization of influenza A virus subtypes in baboon and identification of conserved regions as vaccine targets Emmanuel Kulwa Bunuma
Evaluation of Plasmodium Helical Interspersed  Sub Telemeric (PHISTc) Proteins as Potential Anti-Malarial Vaccine Targets Eunice Wavinya Kiamba
Analysis of Genetic Diversity and Heat Shock Protein 70 (HSPS70) Gene Functional Polymorphisms for Heat Tolerance in Domesticated Rabbits in Kenya Sharon Auma Owuor
Development of point of care Molecular Diagnostics of Malaria in Kenya Kenny Kimani Kamau
Evaluation of Human Epidermal growth factor receptor-2/Neu and Hormonal receptor expression patterns in Breast Cancer from Fine Needle aspiration cytology Dr. Mutinda C. Kyama
Evaluation of Efficacy and Toxicity of Senna Didymoboytra Plant Extracts as Antimalarial Remedy Grace Wambui Kimani
Prevalence, Antimicrobial Susceptibility Profiles and Genetic Diversity of Isolates Obtained from Urine Samples of Pregnant Women Attending Antenatal Clinic at Pumwani Maternity Hospital, Kenya Hellen A. Onyango
Anticancer Potential of Selected Medicinal Plants (Tropical Area) Mohamed Abd Elfattah  Mohamed Hassen (PAUSTI)
Improving Early Diagnosis of Cervical Squamous Intraepithelial Lesions Using P16INK4a Marker on Cell Blocks from Cervical Smears Martha Wakio Maina
Validation of a Smartphone based DNA real time PCR assay for the detection of Human Malaria at Point of Care Lukoye John
Evaluation of Anti-Plasmodium Soybean Extract Nyandwaro Kevin Teya
Evaluation of the Suitability of Human Solid Waste from Green Toilets System as Fertilizers for Agricultureal use Ouma Shellemiah Otieno
Carriage of Staphylococcus Aureus and the prevalence of Methicillin Resistant Staphylococcus Aureus among football players at Camp To yoyo Stadium Bagio Emodoi Antony
validation of selected ethno medicines used in Kenya with potential anti-malaria, analgesic and anti-typhoid agents Prof. John Ochora
Improvement of Disease Management; ‘Genotypic characterization of Mycobacterium tuberculosis Recovered from Newly Diagnosed, Repeat and TB-HIV co-infected Patients Reporting to Clinics in Western Kenya’ Martin Owalla ogwang
JFY 2016/2017
Research Title PI/Researchers
The potental of transgenic (expressing mouse interferon gamma) Plasmodium berghei to induce malaria protection in mice Ebenezer Ninyah Taylor (PAUSTI)
Active prevalence of hepatitis C infection and molecularcharacterization if hepatitis C virus among patients in Rwanda Esperance Umumararungu (PAUSTI)
Validation of sarcosine as a potential antimalarial drug candidate when used singly with combination with quinolone and artemisinin based drugs Jean Baptiste
Genetic diversity of potato (Solanum tuberose) clones conserved in Ethiopia using Simple sequence repeat (SSR) markers Hulubanche Tadele Kassa (PAUSTI)
Repositioning of approved drugs for use against blood stage Plasmodium falciparum in Silico, in vitro and in vivo approach Reagan Moseti Mogire
Molecular markers associated with amodiaquine resistance in rodent malaria parasite Plasmodium berghei ANKA Loise Ndungu
Evaluating efficacy of small interfering RNAs in breaking seed domancy and developing protocols for regeneration and transformation of Rosa rubiginosa Miloane Mokhobo
Characterization of antibiotics and biosynthesized antibacterial silver nanoparticles from actinomycetes isoloated from industrial waste disposal sites Kassahun Abebe Bizuye (PAUSTI)
Evaluation of loop medicated isothermal amplication assay in the detection of falciparum malaria at the lake region in Kenya James Gachugia Mwangi
Prevalence of abnormal urine components in subjectively healthy food handlers attending regular medical checkup at KEMRI CMR Mutua Boniface Wambua
Characterization of human herpes virus type 8 among female sex works in Malinda kenya Mirriam Mbithe Nzivo
Physical activity dietary and nutritional status of hypertensive patients attending kiambu district hospital, Kiambu county Kenya Jane Gatwiri Mbijiwe
Genotype identification of toxoplasma gondii strains associated with toxoplasmosis in Kenya Ngugi Jedidah Njeri
Isolation and characterization of novel alkalithermophilic bacteria from the hot springs of lake Magadi Eunice Mbuli Mulango
Isolation and characterization of gut microbes present in wild and captive baboon population Senelwa Davis Lugano
Analysis of resistance of transgenic potato varieties to selected phytophthora infestans isolates Ethel Webi
Characterization of human T cell lymphotropic virus among intravenous drug users in Malindi, Kenya Caroline  Chepkorir Koech
Polymorphism in growth hormone and myostatin gene associated with meat production traits in domesticated rabbits in Kenya Festus Mutai Kiprono
The utility of a low cost manual liquid based cytology in screening for precancerous lesions and cervical cancer Onesmus Muia
Differential antibiotic resistance of Helicobacter pylori in dyspeptic patients: a study on genetic and phenotypic diversity among clinical isolation from gastric corpus and antrum Catherine Njeri Mwangi
Genotypic characterization of mycobacterium tuberculosis recovered for newly diagnosed, repeat and TB HIV confected patients reporting to clinics in Western Kenya Martin Owallah
Antimicrobial , immunomodulatory effects, safety evaluation and partial characterization of Kenyan Cape Gooseberry (Physalis Peruviana) extracts Peter Karanja Kamau
JFY 2015/2016
Research Title PI/Researchers
Phytochemical and pharmacological evaluation of medicinal plants used as contraceptives in Siaya county, Kenya Rechab Sylvester Odhiambo
Dietary regulation of highly polyunsaturated fatty acids content in farmed tilapia (Oreochromis  niloticus) and cat fish (Clarias gariepinus) Kevin Mbogo Omolo
Prevalece, plasmids and antibiotic resistance correlation of enteric bacteria in waste water, surface water and drinking water biofilms in Nairobi river Basin, Kenya. Mwangi Samuel Wambura
Antimicrobial and cytotoxic effects of secondary metabolites from endophytic and epiphytic bacteria and fungi from marine algae of the Kenya coast. Purity Kinya Kaaria
Evaluating antiplasmodial activity of a novel compound in mouse model and in vitro Muturi Njokah
Determining the presence of fungal pathogens and concentration levels of aflatoxin in commonly used food spices in Kiambo county and the public health risks associated with consumption of the spices Moses Odanga
Pathophysiological manifestations in Olive baboons (Papio Anubis) experimentally infected with toxoplasma gondii strain isolated from free range chicken Dr. David Muchina Kamau
Antimicrobial, immunomodulatory effects, safety evaluation and partial characterization of Kenyan Cape Gooseberry (Physalis peruviana L) extracts. Peter Karanja Kamau
Functional determination of tricon protease in trypanosome brucei through site directed mutagenesis Florence Atieno Ng’ong’a
Molecular characterization of different aspergillus flavus isolates from different agroecological regions in Kenya. Biwott Edwin Kimurgor
Hypoglycemic potential and phytochemical screening of aloe secundiflora and aloe lateritia extracts in Alloxan induced diabetic mice. Charles Makau Mbithi
Seroprofile, genetic diversity, antiretroviral resistance and role of cytokines in defining disease progression among hepatitis B and HIV co-infected individuals visiting Mama Lucy hospital, Nairobi. Sepha Nyatich Mabeya (PAUSTI)
Antimicrobial, immunjomodulatory effects, safety evaluation and partial characterization of Kenyan Cape Gooseberry (Physalis peruviana L) extracts. Peter Mochama Onkware
JFY 2014/2015
Research Title PI/Researchers
Impact of enclosures and afforestation on forage production in rangelands in West Pokot, Kenya Regina Waiganjo
Bio prospecting for Novel Antibiotics from soil actinomycets Mercy Chepkurui
Hybrid drugs: Future to malarial chemotherapy efficacy and toxicity of chloroquine derived hybrid drug in vitro and in vivo Milka Wambui
Bacterial diversity in the midnight of Anopheles gambiae mosquito vectors in selected parts of Kenya Erastus Mwaringa
Phylogeographer and population genetic structure of naked mole rate Heterocephalus glaber Phillip Moshe
Genetic background and functional polymorphisms of candidate gene for draught tolerance of indigenous chickens in Kenya Kennedy Grace Moraa