iCMoB Funded Innovative Research Projects 2014-2023
| JFY 2023/2024 | ||
| Research Title | PI | Student/Researcher |
| Phytochemical Profiling and Molecular Mechanism of Hydnora Abyssinica and Vitex Doniana Against Cervical Cancer Cell Lines | Prof. Mutinda Kyama |
Amel Elbasyoun |
| Characterization and Antibacterial Activity of Environmental Lytic Bacteriophages Against Clinical Isolates of Multidrug-resistant Enterococcus Faecalis and Enterococcus Faecium | Dr. Andrew K. Nyerere |
Oumarou Soro |
| Molecular Xenomonitoring of Onchocerca Volvulus in Kenya: Improved Control Towards Disease Elimination | Dr. Amos Mbugua |
Esther A. Omondi |
| Detection and Molecular Characterization of Human Cytomegalovirus Infection Among Pregnant Women Attending the Antenatal Clinic at Kenyatta National Hospital. |
Ruth W. Gicho |
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| Assessment of the Role of Variant Surface Antigen Protein (Var2csa) In Antibody-Mediated Complement Activation in Pregnancy Associated Malaria |
Alex R. Kiplagat |
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| Correlation of Antimicrobial Resistance Profiles of Isolates Recovered from Patients’ Clinical Specimens and Those Recovered from Hospital Abiotic Surfaces of Kenyatta National Hospital |
Joel S.K. Mukaya |
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| Development of an Antimicrobial Surface Coatings Containing Metal/Metal Oxide Nanoparticles Synthesized using Non-Pathogenic Fungi | Dr. Edwin Madivoli |
Vincent M. Ngunjiri |
| JFY 2022/2023 | ||
| Research Title | PI | Student/Researcher |
| Evaluation of endometrial cytology in detection of endometrial cancer and atypical hyperplasia | Prof. Mutinda Kyama | Eudia Kemei |
| Phytochemical profiling of selected male fertility enhancing medicinal plants from Meru county, Kenya | Prof. Patrick Kareru | Brenda Akinyi Ogwenya |
| Prevalence, associated risk factors, antimicrobial profiles and genotypic characterization of campylobacter species in diarrheic children under five years at Mbagathi Hospital Nairobi | Dr. Celestine Makobe | Mr. Peter Abuom |
| Genotyping of virulence and antimicrobial resistant genes in biofilm forming Escherichia coli isolates from patients with Urinary tract infection in Kenya. | Dr. Caroline Ngugi | Shirleen Chelagat |
| Potential use of bacteriophage for pathogen reduction in sewage effluent and sludge. Case study: Ruai sewage treatment plant | Dr. Juliah Khayeli | Ms. Noreen Juma |
| Efficacy of nano-phytoconstituents from indigenous Kenyan medicinal plants against drug-resistant Mycobacteria tuberculosis (M. tb) | Prof. Patrick Gachoki Kareru | Brian Victor Otenda |
| Evaluation of a nitrogen removal system to limit water exchange for closed recirculating freshwater system using Down flow hanging sponge (DHS)– up flow sludge blanket system (USB) reactor in growing of Labeo spp. in Kenya | Dr. Robert Nesta | Calvin Owuor Obondo |
| The dynamics of SARS CoV 2 specific T cell responses among the Kenyan population to guide diagnosis and treatment of SARS CoV 2 and other viral infection pandemics | Dr. Amos Mbugua | Gladwell Gathigia Ndoria |
| In vivo efficacy of anti-leishmanial activity of Allium sativum and Aloe secundiflora extracts. | Dr. Christine Mutoro | – |
| Defining the Role of Plasmodium falciparum Proteasome Shuttle Proteins in Artemisinin Resistance | Dr. Edinah Song’oro | – |
| JFY 2021/2022 | ||
| Research Title | PI | Student/Researcher |
| Improving the socio-economic status of dairy goat farmers in Kiambu and Nyeri Counties by the control of Mastitis | Dr. Caroline Ngugi | – |
| CRISPR_Cas9 based validation of SufS and ISCS genes association with drug resistance in Plasmodium falciparum | Dr. Daniel Kiboi | Beatrice M. Gachie |
| The immune response and physiological effects of covid-19 vaccine among health workers at Kenyatta university teaching, referral and research hospital | Dr. Caroline Ngugi | Joyce Muthoni Gachoki |
| Evaluation of The Effects of Dermaseptin B2 on Tumorigenesis in Vitro and in A Mouse Model with Rhabdomyosarcoma | Prof. Fred Wamunyokoli | Ahmed A. Abdille |
| Evaluation of β-Tubulin SNPs associated with drug resistance in soil-transmitted helminths | Dr. Amos Mbugua | Peterson M. Maingi |
| Development and evaluation of the performance efficiency for a low-cost solar-powered aquaponics system for small-holder farmers in Kenya | Dr. Robert Nesta | – |
| JFY 2020/2021 | ||
| Research Title | PI | Student/Researcher |
| Development of SARS-CoV-2 spike RBD Biosensor for the Screening of Patients with Coronavirus Disease of 2019 | Dr. Mutinda Kyama | |
| Development of Monoclonal Antibodies and Evaluation of Their Efficacy in The Neutralization of Naja Ashei (Large Brown Spitting Cobra) Venom and Detection of Envenomation | Dr. Mutinda Kyama | Ernest Ziem Manson |
| Molecular Biomarkers for Diagnosis of induced Endometriosis in Baboon Model | Dr. Mutinda Kyama | Irene Mwongeli Waita |
| Prevalence, Antifungal Susceptibility and Genotypic Characterization of Isolated Candida Species from Bloodstream Of CCU Patients In Nairobi Hospital, Kenya | Dr. Caroline Ngugi | Danait Andemichael Solomon |
| Antimicrobial Susceptibility Profiles And Molecular Basis Of Resistance Of Escherichia Coli And Klebsiella Pneumoniae Strains Isolated From Wastewaters In Nairobi And Its Environs, Kenya | Dr. Caroline Ngugi | Osborn Khasabuli |
| Lymphocyte Adaptor Protein Gene As A Molecular Marker For The Detection Of Essential Hypertension | Dr. Amos Mbugua | Caroline Wayua Mumo |
| Development of Bromelainencapsulated with Zinc Oxide Nanoparticles for Treatment of Gastrointestinal Parasites in Dairy Goats from Small Holder Farms in Greater Thika Region | Dr. Kenneth Ogila | Oduor Michael |
| Evaluation of Anti-Dengue Properties of Carica Papaya Leaf Extract Coated Silver Nanoparticles and in Silico Optimization of The Bioactive Compounds | Dr. Florence Ng’on’ga | Antonia Windkouni |
| In vitro Investigation of Acyclovir Derivatives Potency against Herpes simplex virus | Dr. Florence Ng’on’ga | Clive Nyaribo |
| Dissecting the Association of Major Transporters with Resistance to Antimalarial Drugs; Piperaquine, Lumefantrine and Amodiaquine in Plasmodium Berghei | Dr. Daniel Kiboi | Brendah Mureithi |
| Genetic Polymorphisms in Estrogen Metabolism Enzymes in Patients Diagnosed with Estrogen Receptor Positive Breast Cancer at Aga Khan University Hospital, Nairobi | Dr. Steven Ger | Mary Mureithi |
| Building a national capacity for research development and production of bacteriophage-based antibacterial agents against antimicrobial-resistant bacteria in Kenyan fish farms. | Dr. Josephine Kimani | |
| JFY 2018/2019 | ||
| Research Title | PI/Researchers | |
| Development of an Oral Dosage Form from Kenya Ruellia Prostrata Species for Management of Rheumatoid Arthritis | Dr. Christine Ong’ayo Wangia | |
| Drug Development of Nano formulated Azadirachta Indica as Anticancer Therapy | Judith Nwagbogu (PAUSTI) | |
| A Pre-Clinical Mouse Model to Test New Therapeutic Agents and New Diagnostic Biomarkers for Ovarian Cancer | Dr. Mutinda Kyama & Dr. Andrew Nyerere | |
| Development of Ph Responsive Smart Delivery Hydrogels for Wound Dressing Application | Edwin Shigwenya Madivoli | |
| Development of Methods of Detection and Characterization of MLN-Casual Viruses using Small RNA Transcriptome Profiling | Tanui Ronald (PAUSTI) | |
| HIV-1 Genetic Diversity, Tropism, Transmitted and Acquired drug Resistance Mutations Among HIV infected patients attending Comprehensive Care Clinic in Kisii Teaching and Referral Hospital, Kenya | Sepha Nyatichi Mabeya | |
| Evaluating the Medicinal Potential of the Crude Extracts and Peptides Isolated Peptides from Tympanotous Fuscatus Var Radula and Pachymelania | EGHIANRUWA, Queensley Adesuwa (PAUSTI) | |
| JFY 2017/2018 | ||
| Research Title | PI/Researchers | |
| Immunomodulatory and Plesctanthus Barbatus Extracts in Alloxan | Evelyn Kagendo Kirugara | |
| Genetic characterization and in vitro regeneration of Garcinia kola (Heckel)-A medicinal tree in Benin(West Africa) | Dadjo Colombe Pritania Adeline Fifamin (PAUSTI) | |
| HIV-1 Genetic Diversity, Viral Tropism, Transmitted and Acquired Drug Resistance Mutations among Patients attending Comprehensive Care Clinic in Kisii Teaching and Referral Hospital Kenya | Sepha Nyatichi Mabeya | |
| Antibacterial Properties of Medicinal Plants used among the Maasai Community in Kenya | Kariuki Mercy Wanjiru | |
| Comparative Analysis of Random Blood Glucose Levels in Serum Plasma and Whole Blood Using Glucose Oxidase and Hexokinase Methods | Joyce Muthoni Gachoki | |
| Genetic Characterization of Gametocyte Development Protein I and PFAPS-G in Plasmodium Falciparum Isolates Background | Josphat Kipsang Bungei | |
| Bio-prospecting for Antimicrobial and Anticancer Peptides from Marine Organisms Tympanotonus fuscatus var radula and Pachymelania aurita | EGHIANRUWA, Queensley Adesuwa (PAUSTI) | |
| Identification of Candidate Targets for retroviral Protease Inhibitors in Plasmodium Berghei | Noah Machuku Ochieku | |
| Molecular characterization of influenza A virus subtypes in baboon and identification of conserved regions as vaccine targets | Emmanuel Kulwa Bunuma | |
| Evaluation of Plasmodium Helical Interspersed Sub Telemeric (PHISTc) Proteins as Potential Anti-Malarial Vaccine Targets | Eunice Wavinya Kiamba | |
| Analysis of Genetic Diversity and Heat Shock Protein 70 (HSPS70) Gene Functional Polymorphisms for Heat Tolerance in Domesticated Rabbits in Kenya | Sharon Auma Owuor | |
| Development of point of care Molecular Diagnostics of Malaria in Kenya | Kenny Kimani Kamau | |
| Evaluation of Human Epidermal growth factor receptor-2/Neu and Hormonal receptor expression patterns in Breast Cancer from Fine Needle aspiration cytology | Dr. Mutinda C. Kyama | |
| Evaluation of Efficacy and Toxicity of Senna Didymoboytra Plant Extracts as Antimalarial Remedy | Grace Wambui Kimani | |
| Prevalence, Antimicrobial Susceptibility Profiles and Genetic Diversity of Isolates Obtained from Urine Samples of Pregnant Women Attending Antenatal Clinic at Pumwani Maternity Hospital, Kenya | Hellen A. Onyango | |
| Anticancer Potential of Selected Medicinal Plants (Tropical Area) | Mohamed Abd Elfattah Mohamed Hassen (PAUSTI) | |
| Improving Early Diagnosis of Cervical Squamous Intraepithelial Lesions Using P16INK4a Marker on Cell Blocks from Cervical Smears | Martha Wakio Maina | |
| Validation of a Smartphone based DNA real time PCR assay for the detection of Human Malaria at Point of Care | Lukoye John | |
| Evaluation of Anti-Plasmodium Soybean Extract | Nyandwaro Kevin Teya | |
| Evaluation of the Suitability of Human Solid Waste from Green Toilets System as Fertilizers for Agricultureal use | Ouma Shellemiah Otieno | |
| Carriage of Staphylococcus Aureus and the prevalence of Methicillin Resistant Staphylococcus Aureus among football players at Camp To yoyo Stadium | Bagio Emodoi Antony | |
| validation of selected ethno medicines used in Kenya with potential anti-malaria, analgesic and anti-typhoid agents | Prof. John Ochora | |
| Improvement of Disease Management; ‘Genotypic characterization of Mycobacterium tuberculosis Recovered from Newly Diagnosed, Repeat and TB-HIV co-infected Patients Reporting to Clinics in Western Kenya’ | Martin Owalla ogwang | |
| JFY 2016/2017 | ||
| Research Title | PI/Researchers | |
| The potental of transgenic (expressing mouse interferon gamma) Plasmodium berghei to induce malaria protection in mice | Ebenezer Ninyah Taylor (PAUSTI) | |
| Active prevalence of hepatitis C infection and molecularcharacterization if hepatitis C virus among patients in Rwanda | Esperance Umumararungu (PAUSTI) | |
| Validation of sarcosine as a potential antimalarial drug candidate when used singly with combination with quinolone and artemisinin based drugs | Jean Baptiste | |
| Genetic diversity of potato (Solanum tuberose) clones conserved in Ethiopia using Simple sequence repeat (SSR) markers | Hulubanche Tadele Kassa (PAUSTI) | |
| Repositioning of approved drugs for use against blood stage Plasmodium falciparum in Silico, in vitro and in vivo approach | Reagan Moseti Mogire | |
| Molecular markers associated with amodiaquine resistance in rodent malaria parasite Plasmodium berghei ANKA | Loise Ndungu | |
| Evaluating efficacy of small interfering RNAs in breaking seed domancy and developing protocols for regeneration and transformation of Rosa rubiginosa | Miloane Mokhobo | |
| Characterization of antibiotics and biosynthesized antibacterial silver nanoparticles from actinomycetes isoloated from industrial waste disposal sites | Kassahun Abebe Bizuye (PAUSTI) | |
| Evaluation of loop medicated isothermal amplication assay in the detection of falciparum malaria at the lake region in Kenya | James Gachugia Mwangi | |
| Prevalence of abnormal urine components in subjectively healthy food handlers attending regular medical checkup at KEMRI CMR | Mutua Boniface Wambua | |
| Characterization of human herpes virus type 8 among female sex works in Malinda kenya | Mirriam Mbithe Nzivo | |
| Physical activity dietary and nutritional status of hypertensive patients attending kiambu district hospital, Kiambu county Kenya | Jane Gatwiri Mbijiwe | |
| Genotype identification of toxoplasma gondii strains associated with toxoplasmosis in Kenya | Ngugi Jedidah Njeri | |
| Isolation and characterization of novel alkalithermophilic bacteria from the hot springs of lake Magadi | Eunice Mbuli Mulango | |
| Isolation and characterization of gut microbes present in wild and captive baboon population | Senelwa Davis Lugano | |
| Analysis of resistance of transgenic potato varieties to selected phytophthora infestans isolates | Ethel Webi | |
| Characterization of human T cell lymphotropic virus among intravenous drug users in Malindi, Kenya | Caroline Chepkorir Koech | |
| Polymorphism in growth hormone and myostatin gene associated with meat production traits in domesticated rabbits in Kenya | Festus Mutai Kiprono | |
| The utility of a low cost manual liquid based cytology in screening for precancerous lesions and cervical cancer | Onesmus Muia | |
| Differential antibiotic resistance of Helicobacter pylori in dyspeptic patients: a study on genetic and phenotypic diversity among clinical isolation from gastric corpus and antrum | Catherine Njeri Mwangi | |
| Genotypic characterization of mycobacterium tuberculosis recovered for newly diagnosed, repeat and TB HIV confected patients reporting to clinics in Western Kenya | Martin Owallah | |
| Antimicrobial , immunomodulatory effects, safety evaluation and partial characterization of Kenyan Cape Gooseberry (Physalis Peruviana) extracts | Peter Karanja Kamau | |
| JFY 2015/2016 | ||
| Research Title | PI/Researchers | |
| Phytochemical and pharmacological evaluation of medicinal plants used as contraceptives in Siaya county, Kenya | Rechab Sylvester Odhiambo | |
| Dietary regulation of highly polyunsaturated fatty acids content in farmed tilapia (Oreochromis niloticus) and cat fish (Clarias gariepinus) | Kevin Mbogo Omolo | |
| Prevalece, plasmids and antibiotic resistance correlation of enteric bacteria in waste water, surface water and drinking water biofilms in Nairobi river Basin, Kenya. | Mwangi Samuel Wambura | |
| Antimicrobial and cytotoxic effects of secondary metabolites from endophytic and epiphytic bacteria and fungi from marine algae of the Kenya coast. | Purity Kinya Kaaria | |
| Evaluating antiplasmodial activity of a novel compound in mouse model and in vitro | Muturi Njokah | |
| Determining the presence of fungal pathogens and concentration levels of aflatoxin in commonly used food spices in Kiambo county and the public health risks associated with consumption of the spices | Moses Odanga | |
| Pathophysiological manifestations in Olive baboons (Papio Anubis) experimentally infected with toxoplasma gondii strain isolated from free range chicken | Dr. David Muchina Kamau | |
| Antimicrobial, immunomodulatory effects, safety evaluation and partial characterization of Kenyan Cape Gooseberry (Physalis peruviana L) extracts. | Peter Karanja Kamau | |
| Functional determination of tricon protease in trypanosome brucei through site directed mutagenesis | Florence Atieno Ng’ong’a | |
| Molecular characterization of different aspergillus flavus isolates from different agroecological regions in Kenya. | Biwott Edwin Kimurgor | |
| Hypoglycemic potential and phytochemical screening of aloe secundiflora and aloe lateritia extracts in Alloxan induced diabetic mice. | Charles Makau Mbithi | |
| Seroprofile, genetic diversity, antiretroviral resistance and role of cytokines in defining disease progression among hepatitis B and HIV co-infected individuals visiting Mama Lucy hospital, Nairobi. | Sepha Nyatich Mabeya (PAUSTI) | |
| Antimicrobial, immunjomodulatory effects, safety evaluation and partial characterization of Kenyan Cape Gooseberry (Physalis peruviana L) extracts. | Peter Mochama Onkware | |
| JFY 2014/2015 | ||
| Research Title | PI/Researchers | |
| Impact of enclosures and afforestation on forage production in rangelands in West Pokot, Kenya | Regina Waiganjo | |
| Bio prospecting for Novel Antibiotics from soil actinomycets | Mercy Chepkurui | |
| Hybrid drugs: Future to malarial chemotherapy efficacy and toxicity of chloroquine derived hybrid drug in vitro and in vivo | Milka Wambui | |
| Bacterial diversity in the midnight of Anopheles gambiae mosquito vectors in selected parts of Kenya | Erastus Mwaringa | |
| Phylogeographer and population genetic structure of naked mole rate Heterocephalus glaber | Phillip Moshe | |
| Genetic background and functional polymorphisms of candidate gene for draught tolerance of indigenous chickens in Kenya | Kennedy Grace Moraa |